Flash Chromatography System with Online Mass Spec (Model no: Rf+ PurIon)

  • Manufacturer:
    Teledyne Isco
  • Country of Origin:
  • Applications:
    Separation and purification of organic compounds in pharmaceuticals, medicinal chemistry, natural products, agricultural chemicals, cosmetics, flavors & fragrances, etc.

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Product Details

CombiFlash Rf+ PurIon – Verify before you purify


The CombiFlash Rf+ PurIon takes the guesswork out of your purification routine with mass-directed purification. Identify your peak of interest at the time of elution with the advantage of targeted fraction collection. Simply instruct the flash system to collect only those peaks matching the mass of your target compound, eliminating the need for further analysis and saving time in post-purification processing.


As with all other CombiFlash models, Teledyne Isco’s intuitive PeakTrak software lets you access all the commands you need from a single touchscreen. The method development screen facilitates confirmation of the detectable ions of your product, and helps you identify and set appropriate detection parameters prior to the purification process.


Standard Features

  • Real-time method editing and control
  • Touch-and-drag gradients
  • Real-time and post-run MS and UV spectral display
  • Flow rates to 200 mL/min at pressures up to 200 psi (13.8 bar)
  • Compatible with column sizes from 4 to 330 grams
  • Mass range from 50 to 1200 Dalton with 1 Dalton resolution
  • Use with your choice of ELSD, UV, or UV-Vis detectors
  • Reaction monitoring capability



  • Organic synthesis purification
  • Agricultural chemicals
  • Medicinal chemistry
  • Peptides and polymers




10.4 inch touchscreen (26.4 cm), or external web browser via Ethernet. Data and current run can be accessed by up to 10 remote computers. Front panel USB port to save data and transfer files.

PeakTrak software for:

On-screen method development; Real-time control - change method parameters during a run without pausing; Converting Rf values into solvent gradients; Method scaling -transfer method from one size column to another, from 4 g to 330 g; Converting methods to 3000 g columns on CombiFlash Torrent; Color-coded fraction identification.

Remote Wireless Access:

Monitor system operation while away from the lab using iPad, iPhone, or iPod. Change conditions on the fly.

Programmable gradients:

Linear and/or step gradients. Change profiles anytime during run, using "Click and drag" gradients. Pause gradient for isocratic hold.

Pumping system:

Positive displacement pumps. 5-200 mL/min. 0-200 psi (when used with RediSep Rf columns)

Number of Solvents:

Binary gradient with any two of four solvents; A third solvent can be used to add modifier at a fixed percentage.

Gradient Formation:

Low pressure gradient formation, Accuracy <2% full scale; Linear, step, isocratic mixing capability

Auto-Method (RFID):

RFID column detection, RFID Test Tube Rack identification

Column sizes:

4 g to 330 g.

Fraction collection:

Internal fraction collector capacity- 13x100 mm tubes - 216, 16x125/150 mm tubes - 150, 18x150/180 mm tubes - 140, 25x150 mm tubes - 60, 40 mL scintillation vials - 60, 20 mL scintillation vials - 54, 480 mL bottles - 12.

Fraction Size:

Determined by peak cutting and by user-defined maximum tube volume

Sample injection:

Auto-inject with 6-position automated motorized sample loading valve; self-cleans at end of run; solid or liquid injection


Software selectable variable wavelength UV, 200-360 nm; optional variable wavelength UV-Vis, 200-780 nm. slope and threshold peak detection; detector range- 0.2-2.4 AUFS; determination of peak purity by wavelength ratios.

ELSD Detection:

Option that can be combined with either UV or UV-Vis

Mass Spectrometry Detection:

50 - 1200 Dalton, 1 Dalton Resolution; Electrospray Ionization (ESI); or optional Atmospheric Pressure Chemical Ionization (APCI);Positive or Negative Ionization Mode


Static dissipating tubing, vapor sensor, and column air purge.

Sample security:

Auto-run extension at end of run, and over pressure sensor.

Solvent management:

Four solvent and one waste fluid level monitoring

Dimensions(H x W x D):

CombiFlashRf: 60 x 36 x 43 cm

Mass Spectrometer: 66 x 28 x 56 cm

Roughing Pump: 26 x 23 x 46 cm